Researchers at Rhode Island Hospital's Alzheimer's Disease and Memory Disorders Center have found positive associations between fish oil supplements and cognitive functioning as well as differences in brain structure between users and non-users of fish oil supplements.
The results were reported at the recent International Conference on Alzheimer's Disease, in Paris, France. The NIH-funded study that followed 819 older adults with normal cognition, mild cognitive impairment, and Alzheimer's Disease for over three years with periodic memory testing and brain MRIs. 117 of the subjects reported regular use of fish oil supplements before entry and during study follow-up. The researchers compared cognitive functioning and brain atrophy for patients who reported routinely using these supplements to those who were not using fish oil supplements.
Compared to non-users, use of fish oil supplements was associated with better cognitive functioning during the study. Consistent with the cognitive outcomes, these observations were significant only for those who were APOE4 negative. The researchers found fish oil use was associated with less brain shrinkage.
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