Salmon calcitonin treatment increased proteoglycan and collagen synthesis in human osteoarthritic (OA) cartilage, according to journal BMC Musculoskeletal Disorders. In addition to its well-established effect on subchondral bone, calcitonin may prove beneficial to the management of joint diseases through direct effects on chondrocytes.
Human OA cartilage explants were cultured with salmon calcitonin. Direct effects of calcitonin on articular cartilage were evaluated by 1) measurement of proteoglycan synthesis 2) quantification of collagen type II formation 3) QPCR expression of the calcitonin receptor in OA chondrocytes 4) activation of the cAMP signaling pathway 5) investigations of metabolic activity.
QPCR analysis and subsequent sequencing confirmed expression of the calcitonin receptor in human chondrocytes. All doses of salmon calcitonin significantly elevated cAMP level.
Bonnie - salmon calictonin has been around forever and is by prescription only.
Monday, April 26, 2010
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment