FQ antibiotic discouraged for UTI

The aim of this Annals of of Clinical Microbiology and Antimicrobials study was to determine the antimicrobial susceptibility patterns of urinary isolates from community acquired acute uncomplicated urinary tract infections (uUTI) and to evaluate which antibiotics were empirically prescribed in the outpatient management of uUTI.

The most common isolated uropathogen was Escherichia coli (E. coli) (71.3%). The resistance rates of E. coli isolates for ampicillin, ampicillin-sulbactam, amoxicillin-clavulonate, cefuroxime, ceftriaxone, fluoroquinolones (FQ), co-trimoxazole (TMP-SMX) and gentamicin were 55.1%, 32.7%, 32.7%, 23.4%, 15.9%, 25.2%, 41.1%, 6.1% respectively. FQ were the most common prescribed antibiotics (77.9%), followed by TMP-SMX (10.7%), fosfomycin (9.2%), nitrofurantoin (2.1%). Treatment durations were statistically longer than the recommended 3-day course. Empirical use of FQ in uUTI should be discouraged because of increased antimicrobial resistance rates.

Bonnie - E.Coli showed some resistance to all of the antibiotics. Not surprising. That is why in many of my clients who have had UTIs, antibiotics did nothing.