Scientists at the Johns Hopkins Kimmel Cancer Center have discovered how two cancer-promoting genes enhance a tumor’s capacity to grow and survive under conditions where normal cells die. The knowledge, they say, may offer new treatments that starve cancer cells of a key nutrient - sugar. However, the scientists caution that research does not suggest that altering dietary sugar will make any difference in the growth and development of cancer. “Cancer cells adapt to living within the inner layers of a tumor, a place where circulating nutrients are relatively scarce,” says Nickolas Papadopoulos, Ph.D., associate professor at the Johns Hopkins Kimmel Cancer Center. “We wanted to know what makes these cancer cells survive under such conditions.”
The findings are published in the August 6 issue of Science Express.
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