Monday, June 15, 2009

Research Highlights - June

Journal Nutrition

Several dietary substances have been hypothesized to influence the risk of preeclampsia. The aim of this study was to estimate the association between dietary patterns during pregnancy and the risk of preeclampsia in 23,423 nulliparous pregnant women taking part in the Norwegian Mother and Child Cohort Study. Principal component factor analysis identified 4 primary dietary patterns that were labeled: vegetable, processed food, potato and fish, and cakes and sweets. Women with high scores on a pattern characterized by vegetables, plant foods, and vegetable oils were at decreased risk. Women with high scores on a pattern characterized by processed meat, salty snacks, and sweet drinks were at increased risk.

These findings suggest that a dietary pattern characterized by high intake of vegetables, plant foods, and vegetable oils decreases the risk of preeclampsia, whereas a dietary pattern characterized by high consumption of processed meat, sweet drinks, and salty snacks increases the risk.

American Journal Preventative Medicine

College students maintain a wide array of food and beverages in their dormitory rooms. Parents purchased a substantial amount of food for their children's dormitory rooms, and these food items were less healthful than the food that students purchased. The foods observed in college students' living spaces may have an important impact on eating habits. Overall, young adult–oriented obesity prevention efforts are needed, and improving the various facets of campus food environments may mark an important component of such strategies.

Journal of Allergy and Clinical Immunology

Serum folate levels were inversely associated with total IgE levels. The odds of a high total IgE level, atopy, and wheeze decreased across quintiles of serum folate levels, indicating a dose-response relationship between serum folate levels and these outcomes. Each of these associations remained statistically significant after adjusting for age, sex, race/ethnicity, and poverty index ratio. Higher folate levels were also associated with a lower risk of doctor-diagnosed asthma.

Another study sought to evaluate whether 18-year-old offspring are likely to have the same allergic sensitizations as their parents. Eighteen-year-old participants in an unselected birth cohort and their parents were tested for total and increased levels of allergen-specific IgE to 6 allergens: Dermatophagoides farinae, dog, cat, grass, ragweed, and Alternaria alternata.

In 316 parent-teen triads parental sensitization to any of 6 allergens was associated with teen sensitization to any of those same allergens. An increased risk of matched sensitization was found after adjusting for the spouse's sensitivities and adjusting for other allergens. Risk of maternal matched sensitization with their teen to cat, grass, and A alternata was increased when compared with that seen in teens without parental allergen-specific sensitization. Similarly, a higher than expected risk of paternal matched sensitization with their teen to dog was observed.

In conclusion, parental allergen-specific IgE increases the likelihood of sensitization to the same allergen in young adult offspring.

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