Monday, March 30, 2009

Fish oil pills don't boost benefit of heart drugs

The study tested a 1-gram daily dose of a prescription version of highly purified omega-3 fatty acid — the "good fat" contained in certain oily fish that is thought to help the heart.

Researchers led by Dr. Jochen Senges of the University of Heidelberg gave fish oil or dummy capsules to more than 3,800 people who had suffered a heart attack in the previous two weeks. About 90 percent were already receiving all the medicines recommended to prevent a second attack, including aspirin, anti-clotting and cholesterol drugs.

After a year, it made no difference whether these patients took fish oil or dummy capsules. In both groups, fewer than 2 percent had suffered sudden cardiac death, 4 percent had another heart attack, and fewer than 2 percent had suffered a stroke, according to results presented at an American College of Cardiology conference.

The research doesn't mean that fish oil is of no value. The prescription version used in the study, sold as Omacor and Lovaza in the United States and as Zodin in Europe.

Steve - two reasons for these results:

1) Omacor/Lovaza is manufactured by GlaxoSmithKline and contains partially hydrogenated fat (trans fat). There are no other quality fish oil products we know of that contain trans fat and it is anyone's guess how that can be counterproductive to the EPA/DHA.

2) The most likely reason is the study's structure. The subjects are already on three kinds of drugs that thin the blood enough. What do they think fish oil is going to do on top of that (and 1 gram only as it is)? I would have structured the study with half the subjects receiving 4 grams of fish oil daily with no medication and the other half of the subjects on the three medications with no fish oil. Now that would deliver some powerful results.

1 comment:

Brate said...

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