Tuesday, February 10, 2009

February Research Highlights

American Journal of Clinical Nutrition
  • Consumption of soy foods is associated with a lower risk for colorectal cancer in postmenopausal Chinese women. Bonnie - keep in mind that the population base is Chinese, who predominately consume FERMENTED soy (tofu, tempeh, miso, natto). In the US, we do not consume fermented soy products predominately.
  • Results from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) study of male Finnish smokers aged 50–69 y results support the hypothesis that higher alpha tocopherol concentrations may play a protective role in pancreatic carcinogenesis in male smokers.
  • Women consuming 1272 dietary folate equivalents had a 22% decrease in breast cancer risk compared with women consuming 345. A greater benefit was observed for estrogen-receptor (ER) negative than for ER+ breast cancers. Our study of predominantly supplement users suggests that high intakes of folate averaged over 10 year do not increase breast cancer risk, but may be protective, particularly against ER– breast cancers.

  • Psychological distress (PD) and depressive symptoms are commonly observed during menopausal transition. Studies suggest that omega-3 (n–3) fatty acids may help alleviate depression. To our knowledge, this is the first trial of n–3 supplementation in the treatment of PD and depressive symptoms in middle-aged women. In women with PD without MDE at baseline, the 8-wk changes in PD and depressive scales improved significantly more with E-EPA than with placebo.
  • Vitamin B-12 fortification, analogous to the Folic Acid fortification program, may reduce Neural Tube Defects more than Folic Acid fortification alone. A multicenter randomized controlled trial comparing periconceptional vitamin B-12 in combination with Folic Acid against Folic Acid alone is warranted.
  • While the benefits of folic acid in pregnant women are well understood, choline is little discussed and not often included in prenatal multivitamins. Maternal choline is important normal neural tube closure in the fetus, for neurogenesis in the fetal hippocampus, with effects on memory that persist in adult offspring. The higher the choline intake, the more enhanced the memory performance. Bonnie - our prenatal, Wellness Essentials for Pregnancy, is one of the few that contains choline.

Journal Nutrition
  • Compared with nondrinkers, regular drinking of green tea was associated with a slightly decreased risk for breast cancer. Among premenopausal women, reduced risk was observed for years of green tea drinking and a dose-response relationship with the amount of tea consumed per month was also observed. COMT rs4680 genotypes did not have a modifying effect on the association of green tea intake with breast cancer risk.
  • Vegetables and related nutrients are associated with decreased risk of endometrial cancer.
  • This study provides additional evidence that high total fruit intake and certain fruit and vegetable intakes may be associated with a reduced risk of colorectal adenomas.
  • Vitamin A stores were positively associated with several measures of innate immune activity across a broad range of stores, suggesting that vitamin A enhances protection against diverse pathogens even at concentrations above those needed to maintain normal vision.
  • Bovine Whey Protein Extract can enhance innate immunity by priming normal human blood neutrophils.

American Journal Preventive Medicine
  • This review suggests that SMS-delivered (Text Messages) interventions have positive short-term behavioral outcomes. Further research is required to evaluate interventions for preventive health behaviors that incorporate features found to affect behavioral outcomes and participant acceptance.

Food and Chemical Toxicology
  • Of the 15 pesticides for which quantifiable residues were detected from both domestic and imported fruit and vegetable samples, domestic exposures were significantly higher for 11 pesticides while imported exposures were higher for the remaining four. The five pesticides showing the highest exposures all demonstrated greater domestic exposures than imported exposures. Exposure from pesticides in domestic foods exceeds exposure from imported foods and demonstrates that probabilistic modeling of dietary exposure provides more useful information concerning the relative risks of domestic and imported foods.
  • Solar UV and other ionizing radiations cause a generation of reactive oxygen species, induce cellular DNA damage and alter skin homeostasis. The use of exogenous antioxidants is increasingly frequent. We attempt to demonstrate that a rosmarinic acid extract (rosemary) acts as photo-protector; both free radical scavenger as an inducer of the body’s own endogenous defense mechanisms by regulating tyrosinase activity and stimulating melanin production.
Journal of the American College of Nutrition
  • Honey possesses antimicrobial, antiiviral, antiparasitory, anti-inflammatory, antioxidant, antimutagenic, and antitumor effects. The glycemic load varies depending on the source.

  • Vitamin D supplementation during lactation to support infant and mother is significant for early life vitamin D sufficiency in establishing lifelong health.

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