American Journal Clinical Nutrition
- Polymorphism of the C677T MTHFR homozygote variant (TT) presented a 3.0-fold increased risk of Colorectal Cancer, thus showing an association between different folate intakes on risk of CRC. Bonnie - once again, this shows that incredibly important need to supplement with all three forms of folate (which you will find exclusively in Mmetagenics Actifolate).
- Short-term weight-loss programs based on very-low-calorie diets tend to be unsuccessful in the long term. Clearly, it takes more than simple changes in the macronutrient composition to maintain weight loss, and change in lifestyle must occur at the same time. The frequency of exercise after the diet program is the strongest predictor of weight loss maintenance, while television viewing is associated with weight gain. Current guidelines to prevent weight gain recommend 60 min per day of at least moderate-intensity physical activity. Clinicians should emphasize to their patients that there are no magic ways to lose weight. A healthy diet should be a life-long strategy. To prevent weight cycling, long-term diet approaches with gradual weight loss should be considered a one-way ticket to good health. Bonnie - Amen.
- Among 20,167 men participating in the Physician's Health Study diagnosed with prostate cancer revealed that those consuming fish
5 times/wk had a 48% lower risk of prostate cancer death than did men consuming fish less than once weekly. A similar association was found between seafood n–3 fatty acid intake and prostate cancer mortality.
- Flavonoid intake (tea, apples, pears, chocolate, and broad beans for catechin intake and tea, onions, leek, apples, pears, and sweet peppers for flavonol/flavone intakes) may contribute to maintaining body weight in the general female Dutch population.
- Researchers examined the association between the Mediterranean diet and an established plasma marker of oxidative stress, the ratio of reduced to oxidized glutathione, in a well-controlled study of twins. The association between the Mediterranean diet and plasma oxidative stress is robust and is not confounded by genetic or shared environmental factors. Decreased oxidative stress is a plausible mechanism linking the Mediterranean diet to reduced cardiovascular disease risk. Bonnie - Med diet trascends genetics...whoah.
- Three percent of "kids meals" met all National School Lunch Program criteria. Those that met all criteria offered a side of fruit plus milk. These meals may contribute to the nutritional status of children. Bonnie - may contribute? This is the first analysis done on these awful meals.
The Journal of Nutrition- Rosmarinic Acid (derived from rosemary) may be an effective preventative agent against COX-2 activation by AP-1-inducing agents in both cancer and nonmalignant mammary epithelial cells. Bonnie - one of the active ingrediennts in Metagenics Kaprex.
- Tocotrienols (four of the eight components of vitamin E) have an inhibitory effect on angiogenic factor secretion from cancer cells and revealed the possible mechanisms, providing new information about their antiangiogenic effects.
- Supplementing young women with both zinc and iron protects zinc-related antioxidant indicators previously impaired by iron supplementation without impairment of iron status.
Journal Epigenetics
- Epigenetic modifications play a key role in the patho-physiology of prostate cancer. Histone deacetylases (HDACs) play major roles in prostate cancer progression. HDACs are part of a transcriptional co-repressor complex that influences various tumor suppressor genes. Because of the significant roles played by HDACs in various human cancers, HDAC inhibitors are emerging as a new class of chemotherapeutic agents. HDAC inhibitors have been shown to induce cell growth arrest, differentiation and/or apoptosis in prostate cancer. The combined use of HDAC inhibitors with other chemotherapeutic agents or radiotherapy in cancer treatment has shown promising results. Various HDAC inhibitors are in different stages of clinical trials. In this review we discuss the molecular mechanism(s) through which HDACs influence prostate cancer progression, and the potential roles of HDAC inhibitors in prostate cancer prevention and therapy. Bonnie - zinc is a mineral that assists histone inhibitors.
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