All painkillers of the type known as nonsteroidal anti-inflammatory drugs (NSAIDs) seem to increase the risk of having a heart attack, according to a population-based study conducted in Finland. The finding applies not only to selective COX-2 inhibitors such as celecoxib but also to non-selective drugs like ibuprofen or naproxen.
The investigators evaluated data for 33,309 heart attack patients entered into the Finnish Hospital Discharge Register between 2000 and 2003. These subjects were compared with 138,949 matched "control" subjects.
Helin-Salmivaara from the University of Turku, in Helsinki, and colleagues found that current use of any type of NSAID was associated with 40 percent increased risk of having a heart attack. The risk of having a heart attack tended to decline over time after discontinuation of NSAID use, but this trend reached statistical significance only for nonselective NSAIDs.
In a related editorial, Dr. Deepak L. Bhatt, from Cleveland Clinic Foundation in Ohio, points out that the report by the Finnish team is the largest population-based study of NSAIDs performed to date.
SOURCE: European Heart Journal, July 2006.
Courtesy of Reuters
Steve - as anticipated, the scope of NSAID's effects has widened. More research needs to be undertaken, but I anticipate that many medical scholars and health professionals alike are on high alert. As we have said for years, NSAID's are a band-aid approach for most. One needs to get to the root of the cause, and in most cases, that begins with diet. In addition, there are many nutrients available that can assist with pain relief.
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