Hospitalized patients on proton pump inhibitors (PPIs) were three times as likely to develop diarrhea associated with Clostridium difficile (CDAD) than those who were not taking them, according to a study presented to Interscience Conference on Anti-Microbial Agents and Chemotherapy (ICAAC). The incidence of CDAD has been increasing in many developed countries. The finding makes physiological sense. The stomach is a highly acidic place, something that serves as a major defense mechanism against pathogens. Lowering stomach acid lowers the barrier and permits CDAD more often.
Bonnie - how many more disastrous consequences do we need before we stop taking PPIs long-term?
Friday, September 23, 2011
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