Zinc Deficiency Linked to Esophageal Cancer

People with low levels of zinc in their tissues may be at increased risk for developing cancer of the esophagus, according to research reported in The Journal of the National Cancer Institute.

In the study, investigators determined zinc levels in esophageal biopsy samples obtained from 132 residents of Linzhou, China in 1985. Of these subjects, 60 subsequently developed esophageal cancer and 72 did not.

People in the highest quartile of zinc levels were 79 percent less likely to develop esophageal cancer than those in the lowest quartile, Dr. Christian C. Abnet, from the National Cancer Institute in Bethesda, Maryland, and colleagues report.

This finding supports studies conducted in animals showing that zinc deficiency enhances the effects of certain nitrosamines, which act as esophageal carcinogens in rodents.