We have always been a big supporters of the bioflavanoid, quercetin. While we mainly suggest it for allergy, inflammation, healing, and immune support, we found quercetin's antioxidant properties to be even more ubiquitous.
Ochratoxin (OTA) is one of the most abundant food contaminating mycotoxins and is commonly present in the food chain. Many of the effects associated with OTA, appear to be mediated through oxidative stress. Antidotes for alleviating the toxicity are sparsely reported. In a study in the upcoming December issue of Food and Chemical Toxicology, therapeutic strategy was directed towards use of quercetin. Results demonstrated that quercetin pre-treatment suppressed OTA-induced cytotoxicity and oxidative stress. Quercetin should be investigated to be used as a natural preservative to combat OTA.
Increased Growth factor IGF-1/IGF-1R axis activation is one the most integral factors in the development and progression of prostate cancer. Researchers in the September issue of Clinical Nutrition hypothesized that targeting this system with quercetin could be both treatment as well as prevention of prostate cancer. At least in rats, quercetin down regulated the cell survival, proliferative and anti-apoptotic proteins thereby preventing prostate cancer, by acting as a chemopreventive agent.
Wednesday, October 02, 2013
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