Look AHEAD (Action for Health and Diabetes) is a multisite clinical  trial of 5145 overweight or obese individuals with type 2 diabetes, age  45-76 years. Participants were randomly assigned to either intensive  lifestyle intervention (which involved group and individual meetings to  achieve and maintain weight loss through decreased caloric intake and  increased physical activity) or to general diabetes support and  education (DSE).
The mean age of the participants was 59  years, and 59% of participants were women. Medication costs declined by almost 10% in the lifestyle  group and increased by 10% in the DSE group. The differences were  greatest for diabetes medications: medication costs declined by 17% in  the lifestyle group and increased by 11% in the DSE group. Furthermore,  the intervention more than doubled the percentage of participants who  achieved optimal care goals (from 11% to 24%) and at the same time  reduced medication use and cost. A greater proportion in the DSE group  also achieved optimal care goals at 1 year (increasing from 10% to 16%),  but doing so required an increase in medication use and costs.
The current results have important implications for the cost-benefit  ratio of providing lifestyle interventions; medication cost reductions  must be factored in as an offset to the cost of the programs themselves.  Perhaps lifestyle interventions can help bend the cost curve.
Diabetes Care. 2010;33:1153-1158
Monday, July 12, 2010
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