Wednesday, September 17, 2008

HRT Use Raises Risk of GERD

Women who take hormones to relieve symptoms of menopause have a higher risk of developing symptoms of gastroesophageal reflux disease (GERD).

Also, women who use selective estrogen receptor modulators (SERMs), used to treat breast cancer and osteoporosis, also have a higher risk of developing reflux, according to a study in the Sept. 8 issue of the Archives of Internal Medicine.

In addition, women on oral contraceptives sometimes experience a relaxation of the lower esophageal sphincter, which allows stomach acids to rise up into the esophagus.

The authors of this study reviewed information on 51,637 postmenopausal women enrolled in the Nurses' Health Study. Participants had provided information on both postmenopausal hormone use as well as symptoms of GERD every two years from 1976 through 2002.

Women who had used hormones had a 46 percent higher risk of having symptoms of GERD, compared with women who had never used postmenopausal hormones. Women currently using estrogen only had a 66 percent raised risk while those currently using combined estrogen and progesterone had a 41 percent increased risk.

The chances of developing GERD symptoms were higher with higher doses of hormones and longer duration of use.

Current SERM users had a 39 percent increased risk, while women taking over-the-counter preparations had an increased risk of 37 percent.

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