Topical NSAID's more effective as oral

Gels or creams containing painkillers are better than tablets for chronic knee pain. A study of almost 600 patients over age 50 found the anti-inflammatory creams worked as well as the oral versions and had fewer side-effects. And although they cost more initially, topical treatments may save money in the long run, the Queen Mary University of London researchers said. Those in the study treated with oral medication had more adverse effects such as indigestion, increased blood pressure, or worsening asthma. NSAIDs are well-known to be associated with sometimes serious side effects but the topical preparations deliver a smaller dose directly to the affected area and so are less likely to cause such problems. Patients also preferred the gels and creams, the study which is published on the UK's National Institute for Health Research website.