Monday, November 12, 2007

Antioxidants may stop fat cells formation

Natural antioxidant compounds like flavonoids and phenolic acids could inhibit the formation of fat formation from fat cells, according to a study published in the Journal of Agricultural and Food Chemistry, which looked at the effects of the flavonoids and phenolics on levels of triglyceride in the cells and GPDH activity in 3T3-L1 adipocytes (fat cells).

The researchers chose the 3T3-L1 cell line because it has been used widely for several decades as a cell model for fat cell biology research.

Among the 15 phenolic acids and six flavonoids tested o-coumaric acid and rutin were found to inhibit intracellular triglyceride the most, by 61 and 83 per cent, respectively.

Moreover, the same two compounds were found to be the most potent inhibitors of GPDH, reducing activity by 54 and 67 per cent, respectively.

The compounds also up-regulated expression of adiponectin, a hormone that modulates a number of metabolic processes.

Steve - translation...eat your fruits and vegetables and take your vitamins.

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