Tuesday, December 06, 2005

Aspartame carinogenic in rats

Italian researchers found that apspartame is a multipotential carniogenic agent, even at a daily dose much less than the current acceptable daily intake. Aspartame was administered to 8 week-old rats at varying concentrations. The treatment lasted until natural death. Increased incidence of malignant tumors were exhibited in both male and female rats at multiple concentrations. In particular, lymphomas, leukemias, transitional cell carcinmoas of the renal pelvis and ureter and their precursors (dysplasias), and schwannomas of peripheral nerves were discovered. The researchers plea is as follows: "On the basis of these results, a re-evaluation of the present guidelines on the use and consumption of aspartame is urgent and cannot be delayed."

Steve - This is further clarification of our 12/5/05 post. We recently learned of this study which appeared in Environmental Health Perspectives, published by the National Institute of Environmental Health Sciences. We rarely comment on studies not performed on humans, but given the fact that no substantative study has ever been done on humans with regard to aspartame, we are taking liberty here given the devastating findings the study produced.

1 comment:

  1. Wednesday, December 7, 2005

    Any unsuspected source of methanol, which the body always quickly
    and largely turns into formaldehyde and then formic acid, must be
    monitored, especially for high responsibility occupations, often with
    night shifts, such as pilots and nuclear reactor operators.


    http://groups.yahoo.com/group/aspartameNM/message/1237
    ubiquitous potent uncontrolled co-factors in nutrition research are
    formaldehyde from wood and tobacco smoke and many sources,
    including from methanol in dark wines and liquors, in pectins
    in fruits and vegetables, and in aspartame: Murray 2005.12.07

    http://groups.yahoo.com/group/aspartameNM/message/1250
    aspartame causes cancer in rats at levels approved for humans,
    Morando Soffritti et al, Ramazzini Foundation, Italy &
    National Toxicology Program
    of National Institute of Environmental Health Sciences
    2005.11.17 Env. Health Pers. 35 pages: Murray

    http://groups.yahoo.com/group/aspartameNM/message/1263
    many studies on endothelial injury (diabetic neuropathy) by adducts of
    formaldehyde derived from methylamine from many of the same sources
    as also supply methanol (formaldehyde), including aspartame:
    PH Yu et al: DJ Conklin et al: Murray 2005.12.04

    As a medical layman, I suggest that evidence mandates immediate
    exploration of the role of these ubiquitious, potent formaldehyde
    sources as co-factors in epidemiology, research, diagnosis,
    and treatment in a wide variety of disorders.

    Folic acid, from fruits and vegetables, plays a role by powerfully
    protecting against methanol (formaldehyde) toxicity.

    Many common drugs, such as aspirin, interfere with folic acid,
    as do some mutations in relevant enzymes.

    The majority of aspartame reactors are female.

    In mutual service, Rich Murray
    *******************************************************

    Rich Murray, MA Room For All rmforall@comcast.net
    505-501-2298 1943 Otowi Road Santa Fe, New Mexico 87505

    http://groups.yahoo.com/group/aspartameNM/messages
    group with 149 members, 1,263 posts in a public, searchable archive
    http://RoomForAll.blogspot.com http://AspartameNM.blogspot.com

    Dark wines and liquors, as well as aspartame, provide
    similar levels of methanol, above 100 mg daily, for
    long-term heavy users, 2 L daily, about 6 cans.

    Methanol is inevitably largely turned into formaldehyde,
    and thence largely into formic acid.
    It is the major cause of the dreaded symptoms of "next
    morning" hangover.

    Fully 11% of aspartame is methanol -- 1,120 mg aspartame
    in 2 L diet soda, almost six 12-oz cans, gives 123 mg
    methanol (wood alcohol). If 30% of the methanol is turned
    into formaldehyde, the amount of formaldehyde, 37 mg,
    is 18.5 times the USA EPA limit for daily formaldehyde in
    drinking water, 2.0 mg in 2 L average daily drinking water,

    185 times the New Jersey limit,
    615 times the California and Maine limits,
    1850 times the Maryland limit.

    The 1999 July EPA 468-page formaldehyde profile admits that
    four states substantially exceed the federal EPA limit:

    Environmental Protection Agency 2.00 mg in 2 L daily
    drinking water

    California and Maine------------ 0.06 mg
    Maryland---------------------- 0.02 mg
    New Jersey-------------------- 0.20 mg

    http://groups.yahoo.com/group/aspartameNM/message/1108
    faults in 1999 July EPA 468-page formaldehyde profile:
    Elzbieta Skrzydlewska PhD, Assc. Prof., Medical U. of
    Bialystok, Poland, abstracts -- ethanol, methanol,
    formaldehyde, formic acid, acetaldehyde, lipid peroxidation,
    green tea, aging: Murray 2004.08.08 2005.07.11

    http://groups.yahoo.com/group/aspartameNM/message/835
    ATSDR: EPA limit 1 ppm formaldehyde in drinking water July
    1999: Murray 2002.05.30 rmforall

    Aspartame is made of phenylalanine (50% by weight) and
    aspartic acid (39%), both ordinary amino acids, bound
    loosely together by methanol (wood alcohol, 11%).
    The readily released methanol from aspartame is within hours
    turned by the liver into formaldehyde and then formic acid,
    both potent, cumulative toxins.

    http://groups.yahoo.com/group/aspartameNM/message/1106
    hangover research relevant to toxicity of 11% methanol in
    aspartame (formaldehyde, formic acid): Calder I (full text):
    Jones AW: Murray 2004.08.05 2005.09.28

    Since no adaquate data has ever been published on the exact
    disposition of toxic metabolites in specific tissues in
    humans of the 11% methanol component of aspartame, the many
    studies on morning-after hangover from the methanol impurity
    in alcohol drinks are the main available resource to date.

    Jones AW (1987) found next-morning hangover from red wine
    with 100 to 150 mg methanol (9.5% w/v ethanol, 100 mg/L
    methanol, 0.01%, one part in ten thousand).

    http://groups.yahoo.com/group/aspartameNM/message/1182
    Joining together: short review: research on aspartame
    methanol, formaldehyde, formic acid) toxicity: Murray
    2005.07.08 rmforall

    http://groups.yahoo.com/group/aspartameNM/message/1071
    research on aspartame (methanol, formaldehyde, formic acid)
    toxicity: Murray2004.04.29 rmforall

    http://groups.yahoo.com/group/aspartameNM/message/1250
    aspartame causes cancer in rats at levels approved for humans,
    Morando Soffritti et al, Ramazzini Foundation, Italy &
    National Toxicology Program
    of National Institute of Environmental Health Sciences
    2005.11.17 Env. Health Pers. 35 pages: Murray

    http://groups.yahoo.com/group/aspartameNM/message/1226
    USA National Institutes of Health National Toxicology
    Program aids eminent Ramazzini Foundation, Bologna, Italy,
    in more results on cancers in rats from lifetime low levels
    of aspartame (methanol, formaldehyde), Felicity Lawrence,
    www.guardian.co.uk: Murray 2005.09.30

    http://groups.yahoo.com/group/aspartameNM/message/1186
    aspartame induces lymphomas and leukaemias in rats, full plain text,
    M Soffritti, F Belpoggi, DD Esposti, L Lambertini: Ramazzini
    Foundation study 2005.07.14: main results agree with their previous
    methanol and formaldehyde studies: Murray 2005.09.03

    http://groups.yahoo.com/group/aspartameNM/message/1189
    Michael F Jacobson of CSPI now and in 1985 re aspartame
    toxicity, letter to FDA Commissioner Lester Crawford;
    California OEHHA aspartame critique 2004.03.12; Center for
    Consumer Freedom denounces CSPI: Murray 2005.07.27

    http://groups.yahoo.com/group/aspartameNM/message/1143
    methanol (formaldehyde, formic acid) disposition: Bouchard M
    et al, full plain text, 2001: substantial sources are
    degradation of fruit pectins, liquors, aspartame, smoke:
    Murray 2005.04.02 rmforall

    http://groups.yahoo.com/group/aspartameNM/message/1141
    Nurses Health Study can quickly reveal the extent of aspartame
    (methanol, formaldehyde, formic acid) toxicity: Murray 2004.11.21
    [ Any scientist can get access to this data for free by submitting a proper
    research proposal.
    No one has admitted mining the extensive data on diet soda use
    and many symptoms for decades for about 100,000 nurses. ]

    http://groups.yahoo.com/group/aspartameNM/message/1213
    aspartame (methanol, phenylalanine, aspartic acid) effects, detailed
    expert studies in 2005 Aug and 1998 July, Tsakiris S, Schulpis KH,
    Karikas GA, Kokotos G, Reclos RJ, et al,
    Aghia Sophia Children's Hospital, Athens, Greece: Murray 2005.09.09

    http://groups.yahoo.com/group/aspartameNM/message/939
    aspartame (aspartic acid, phenylalanine) binding to DNA:
    Karikas July 1998: Murray 2003.01.05 rmforall
    Karikas GA, Schulpis KH, Reclos GJ, Kokotos G
    Measurement of molecular interaction of aspartame and
    its metabolites with DNA. Clin Biochem 1998 Jul; 31(5): 405-7.
    Dept. of Chemistry, University of Athens, Greece
    http://www.chem.uoa.gr gkokotos@atlas.uoa.gr
    K.H. Schulpis inchildh@otenet.gr G.J. Reclos reklos@otenet.gr

    http://groups.yahoo.com/group/aspartameNM/message/1088
    Murray, full plain text & critique: chronic aspartame in rats affects
    memory, brain cholinergic receptors, and brain chemistry, Christian B,
    McConnaughey M et al, 2004 May: 2004.06.05

    http://groups.yahoo.com/group/aspartameNM/message/1067
    eyelid contact dermatitis by formaldehyde from aspartame,
    AM Hill & DV Belsito, Nov 2003: Murray 2004.03.30

    Thrasher (2001): "The major difference is that the Japanese
    demonstrated the incorporation of FA and its metabolites into the
    placenta and fetus.
    The quantity of radioactivity remaining in maternal and fetal tissues
    at 48 hours was 26.9% of the administered dose." [ Ref. 14-16 ]

    Arch Environ Health 2001 Jul-Aug; 56(4): 300-11.
    Embryo toxicity and teratogenicity of formaldehyde. [100 references]
    Thrasher JD, Kilburn KH. toxicology@drthrasher.org
    Sam-1 Trust, Alto, New Mexico, USA.
    http://www.drthrasher.org/formaldehyde_embryo_toxicity.html full text

    http://groups.yahoo.com/group/aspartameNM/message/1052
    DMDC: Dimethyl dicarbonate 200mg/L in drinks adds
    methanol 98 mg/L [ becomes formaldehyde in body ]: EU Scientific
    Committee on Foods 2001.07.12: Murray 2004.01.22

    http://groups.yahoo.com/group/aspartameNM/message/925
    aspartame puts formaldehyde adducts into tissues, Part 1/2
    full text Trocho & Alemany 1998.06.26: Murray 2002.12.22

    http://groups.yahoo.com/group/aspartameNM/message/1224
    Aspartame disease: an FDA-approved epidemic, H. J. Roberts,
    MD 2004: Murray 2005.09.30

    http://groups.yahoo.com/group/aspartameNM/message/1233
    Aspartame -- the shocking story, The Ecologist, 2005 Sept.,
    p. 35-51, full text: Murray 2005.09.30: the correct author,
    Pat Thomas, What Doctors Don't Tell You www.wddty.co.uk :
    2005.10.11

    http://groups.yahoo.com/group/aspartameNM/message/1131
    genotoxicity of aspartame in human lymphocytes 2004.07.29
    full plain text, Rencuzogullari E et al, Cukurova University,
    Adana, Turkey 2004 Aug: Murray 2004.11.06

    http://groups.yahoo.com/group/aspartameNM/message/1228
    NM EIB votes 4-2 for 5-day aspartame toxicity hearing July,
    2006, requesting a Hearing Officer and a medical expert from
    Environmental Dept. and legal advice from NM Attorney
    General: Murray 2005.10.04

    http://groups.yahoo.com/group/aspartameNM/message/1237
    ubiquitous potent uncontrolled co-factors in nutrition research are
    formaldehyde from wood and tobacco smoke and many sources,
    including from methanol in dark wines and liquors, in pectins
    in fruits and vegetables, and in aspartame: Murray 2005.12.07
    *******************************************************

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