New research shows women taking the oral contraceptive pill are almost twice as likely to be depressed than those who do not.
The Alfred Psychiatry Research Centre studied 60 women, and found that those taking the pill containing both oestrogen and progesterone were almost twice as likely to be depressed as those who did not.
The centre's director, Professor Jayashri Kulkarni, is urging clinicians to be aware of the psychiatric side effects of the pill.
But she says more research is needed to understand how hormones effect moods.
The Australian Medical Association (AMA) is advising women to continue taking their contraceptive medication, despite the research findings.
AMA vice president Dr Mukesh Haikerwal says if women on the pill are feeling depressed, they should discuss their concerns with their GPs.